International Society of Non-Antibiotics (ISN)

 

 

 Så oprulles skrækscenariet igen også for Dansk Veterinærtidsskrifts læsere.

Læs dyrlæge Søren Nielsens opsigtsvækkende indlæg

Progress in the Basic and Clinical Studies in the

Reversal of Drug Resistance.

Thursday 19 September 2013

at 9.00–19.00

A Symposium on the occasion of the

70th  birthday of

 Dr. Jette Elisabeth Kristiansen

35 years in Paul Ehrlich’s footsteps

”There is no doubt about it: We are really able to reverse resistance using modern methylene blue derivatives”

See the full programme and registration HERE

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Reversering af resistens

(Reversal of Resistance)

Non-antibiotika i behandlingen af infektions-sygdomme forårsaget af følsomme og resistente mikro- organismer hos mennesker og dyr.

Læs artiklen [HER]( Danish)

 Resistente bakterier kan blive følsomme igen (Foodculture.dk d. 14.12.2012 ) 

af Dyrlæge Søren Nielsen, Svendborg. Læs artiklen[HER] (Danish)

President:

  • Professor Sujata Ghosh Dastidar, Ph.D

Research Director

Herbicure Healthcare Bio-Herbal Research Foundation

Saral Dighi (E), Boral, Kolkata-700154

Ex- Professor Emeritus of Microbiology

Department of Pharmaceutical Technology

Jadavpur University, Kolkata- 700032

Vicepresident:

  • Associate Professor Jette E Kristiansen*

Adress: , Sundgade 54, 6320 Egernsund, Denmark

Tel: +45 74 632 888 - E-mail:malthe@dadlnet.dk 

 

Board members:

  • Professor Leonard Amaral, - Instituto de Higiene e Medicina Tropical Universidade Nova de Lisboa,

Rua Junqueira 96 1349-008 Lisboa, Portugal.

E-mail: lamaral@ihmt.unl.pt. -

Website: https://www.researchgate.net/profile/Leonard_Amaral

 

  • Professor Joseph Molnar Szeged, Hungary.

E-mail: molnarj@comser.szote.u-szeged.hu

Website at University of Szeged:www.szote.u-szeged.hu/medmicro/mikro.html

Website at the Szeged Foundation for Cancer Reserach:www.szegedirakkutatasert.hu

Publications Links

 

  • Noton K. Dutta, Ph.D., Faculty, Johns Hopkins School of Medicine, USA

E-mail: ndutta1@jhmi.edu

Website at Johns Hopkins: www.hopkinsmedicine.org/dom/tb_lab/students_staff/noton.html

Publication Links: www.researchgate.net/profile/Noton_Dutta2/publications and

https://scholar.google.com/citations?user=MFjqNw8AAAAJ&hl=en

 

 

Associate members

ISN The Society of Non-Antibiotics is Associate member of the International Society of Chemotherapy (ISC) www.ischemo.org

Articles on non-antibiotics:

NEW in: NATURE CHEMICAL BIOLOGY:

 

Functional mining of transporters using synthetic selections

 

Authors: Hans J Genee,Anne P Bali,Søren D Petersen,Solvej Siedler,Mads T Bonde,Luisa S Gronenberg,Mette Kristensen,Scott J Harrison& Morten O A Sommer

 

http://www.nature.com/nchembio/journal/vaop/ncurrent/full/nchembio.2189.html

 

Abstact:

Only 25% of bacterial membrane transporters have functional annotation owing to the difficulty of experimental study and of accurate prediction of their function. Here we report a sequence-independent method for high-throughput mining of novel transporters. The method is based on ligand-responsive biosensor systems that enable selective growth of cells only if they encode a ligand-specific importer. We developed such a synthetic selection system for thiamine pyrophosphate and mined soil and gut metagenomes for thiamine-uptake functions. We identified several members of a novel class of thiamine transporters, PnuT, which is widely distributed across multiple bacterial phyla. We demonstrate that with modular replacement of the biosensor, we could expand our method to xanthine and identify xanthine permeases from gut and soil metagenomes. Our results demonstrate how synthetic-biology approaches can effectively be deployed to functionally mine metagenomes and elucidate sequence–function relationships of small-molecule transport systems in bacteria.

 

Antimicrobial Effects of selected Non-antibiotics

on Sensitivity and Invasion of Gram-positive Bacteria PhD-Thesis by Oliver Hendrics, University of Southern

Denmark, 2006

 

Modification and Reversal of Resistance in Micro-organisms with Selected Non-antibiotics and their Stereoisomeric Analogs: New Efflux Inhibitors?

Jette E. Kristiansen1, Oliver Hendricks1, Thomas Delvin2, Trine S. Butterworth1 & Jørn B. Christensen3.

The in-vitro antimicrobial effect of non-antibioticsand putative inhibitors of efflux pumps on Pseudomonas aeruginosa and Staphylococcus aureus

O. Hendricks, T. S. Butterworth and J. E. Kristiansen

Links to articles on non-antibiotics:  

The potential management of resistant infections with non-antibiotics 

Reversal of resistance in microorganisms by help of non-antibiotics

IngentaConnect "Non-Antibiotics"- Alternative Therapy for the Management of MDRTB and MRSA in Economically Disadvantaged Countries

The in-vitro antimicrobial effect of non-antibiotics and putative inhibitors of efflux pumps on Pseudomonas aeruginosa and Staphylococcus aureus (International Journal of Antimicrobial Agents)

Potential role of non-antibiotics (helper compounds) in the treatment of multidrug-resistant Gram-negative infections: mechanisms for their direct and indirect activities.

 updated: 02.10.2016 / Piet Jansen webmaster@non-antibiotics.org

 

Society Board members and contacts:

 MRSA – igen – igen !

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